In collaboration with Ghent University, Leiber GmbH has carried out a study with the aim of assessing the potential of the prebiotic activity of Biolex® MB40 within the canine gastrointestinal tract.
Biolex® MB40 consists of cell walls of genuine brewer's yeast (100 percent Saccharomyces cerevisiae) and is distinguished among other factors by its high natural content of β-glucan and Mannan oligosaccharides (MOS).
Biolex® MB40 consists of cell walls of genuine brewer's yeast (100 percent Saccharomyces cerevisiae) and is distinguished among other factors by its high natural content of β-glucan and Mannan oligosaccharides (MOS).
For the study, an in-vitro system (SCIME™ Simulator of the Canine Intestinal Microbial Ecosystem) was deployed, which can retrace the entire canine digestive tract with all its microbiological processes under controlled conditions without working directly with an animal. The SCIME™ delivered not only detailed information about the prebiotic activity of Biolex® MB40 by measuring various biomarkers, but also the precise location of the area where it is active.
In the study that has now been published, a prebiotic effect of Biolex® MB40 on the canine gastrointestinal tract could be demonstrated. Biolex® MB40 is digested moderately and selectively, in particular by the canine microflora in the distal colon. Changes in the metabolic activity were able to be directly associated with specific changes to the microbiota, e.g. the stimulation of propionate–producing families, such as Porphyromonadaceae and Prevotellaceae.
At the same time, potential pathogens, such as Enterobacteriaceae and Fusobacteriaceae were able to be decreased. Biolex® MB40 therefore has a positive influence on the composition and activity of the microorganisms and is a promising natural source for the improvement and protection of intestinal health.
Download the study
"Dried yeast cell walls high in beta-glucan and mannanoligo-saccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro"
by Pieter Van den Abbeele, Cindy Duysburgh, Maike Rakebrandt, Massimo Marzorati
Journal of Animal Science, Volume 98, Issue 6, June 2020
https://doi.org/10.1093/jas/skaa173
Visit the Leiber website, HERE.
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