A recent pair reviewed study published in 'Frontiers in Immunology' demonstrates the capacity of marine algae extracts to modulate immune responses in broilers.
As part of a partnership between Olmix Group and Brest University and Brest Medical School, an in vitro and in vivo study was carried out in order to determine whether a sulphated polysaccharide-rich green algae extract (MSP®IMMUNITY) was able to activate avian neutrophils (heterophils) and monocytes; to identify the pattern recognition receptors (PRR) involved in the initiation of this activation and the molecular pathways in both cellular types; and finally to determine whether a similar effect could be observed in vivo when given per os (orally).
This study showed for the first time that MSP®IMMUNITY activates heterophils (improved glucuronidase release and oxidative burst) and monocytes (higher NO release) through activation of receptors TLR2 and TLR4. The signaling pathways of these receptors displays differences in their ability to induce heterophils degranulation and oxidative burst in vitro. In addition, the activation of heterophils and monocytes leads to an upregulation of the transcription of several immune mediators genes in both cellular types, partly in a cell specific manner. These immune mediators are produced during innate immune responses and play an important role as activators of the adaptive immune response.
Oral administration of MSP®IMMUNITY results in activation of avian neutrophils and monocytes in vivo. Moreover, in vivo activation of heterophils and monocytes led to a transient increase of immune mediators transcription, including interleukin 1-β, interferon-α and interferon-γ suggesting a Th1 orientation of the immune response.
All this suggest that MSP®IMMUNITY could be used to activate animal's innate immune response and promote adaptive one to support their natural defenses and the reduction of the use of antibiotics in farms. MSP®IMMUNITY is one of the algae-based solutions produced by Olmix Group. Created in 1995, the company specialises in harvesting and transforming red, green and brown Breton algae into innovative natural products for the human, animal and plant nutrition and health sectors.
Read the pair reviewed article, HERE.
Visit the Olmix Group website, HERE.
As part of a partnership between Olmix Group and Brest University and Brest Medical School, an in vitro and in vivo study was carried out in order to determine whether a sulphated polysaccharide-rich green algae extract (MSP®IMMUNITY) was able to activate avian neutrophils (heterophils) and monocytes; to identify the pattern recognition receptors (PRR) involved in the initiation of this activation and the molecular pathways in both cellular types; and finally to determine whether a similar effect could be observed in vivo when given per os (orally).
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| Olmix Group researcher Image credit: Olmix Group |
Oral administration of MSP®IMMUNITY results in activation of avian neutrophils and monocytes in vivo. Moreover, in vivo activation of heterophils and monocytes led to a transient increase of immune mediators transcription, including interleukin 1-β, interferon-α and interferon-γ suggesting a Th1 orientation of the immune response.
All this suggest that MSP®IMMUNITY could be used to activate animal's innate immune response and promote adaptive one to support their natural defenses and the reduction of the use of antibiotics in farms. MSP®IMMUNITY is one of the algae-based solutions produced by Olmix Group. Created in 1995, the company specialises in harvesting and transforming red, green and brown Breton algae into innovative natural products for the human, animal and plant nutrition and health sectors.
Read the pair reviewed article, HERE.
Visit the Olmix Group website, HERE.
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