August 16, 2017

17/08/2017: The benefits of use of Phytobiotic HygenPro® in poultry and swine diets

by Ing. Ewa Sujka, DVM Ignacio Lopez, DVM Sonia Tellez. Lípidos Toledo S.A.

In this article, we would like to review the efficacy of phytobiotics used in the different stages of poultry and swine production

We would like to present the mode of action and performance under conditions of intensive production. In the scope of this study will be considered the unique combination of essential oils and organic acids available on the market under the brand HygenPro®.

The usage of antibiotic growth promoters (AGP) in poultry and livestock production was very common along years, however nowadays presents many problems of legal, technical and sanitary nature. 

Image credit: United Soybean Board on Flickr
(CC by 2.0)
From a technical point of view, the main disadvantage is that AGP are not selective over the intestine microbiota, so they affect both pathogen and saprophyte bacteria. Eventually, once the AGP has been excluded from the diet, a delay can be observed in a growing rate and increased incidence of enteric diseases.

It is due to the lack of adaptation of intestine immune system toward bacteria’s that are potential harmful and due to the elimination of beneficial microflora which may counteract this negative impact.

AGP is commonly used zinc oxide, especially in swine production for control of enteric bacteria, however the legal frame for its used become very strict recently, because of environmental contamination.

In the long run zinc oxide presents also technical inconvenience based on the detriment of lactic acid bacteria’s and consequently reduction of feed intake, negative impact on intestine structure and overall on farm performance of the animal.

A described scenario of legal and technical arguments makes the eubiotic feed additives, to gain in popularity and suppose an efficient alternative for antibiotics and zinc oxide used as growth promoters. In this group of ingredients prebiotics, organic acids, enzymes, probiotics and essential oils should be mentioned.

All ingredients are an important progress in pathogen control, however recent studies confirm that the combinations of essential oils with protected organic acids, are the most efficient remedy, to control the growth of intestine bacterial pathogen and significantly improves zootechnical performance.

Organic acids and essential oils are the group of feed additives most common and deeply studied as for use in monogastric species. In vitro trials confirm that essential oils have antibacterial, antioxidant and immunomodulation properties.

The combined action of organic acids together with essential oils shows synergy, in the control pathogen bacteria and the stimulation of growth of saprophyte microflora. Active components have a sparing effect, allowing organic acids to penetrate bacteria cell membranes more efficiently, increasing its permeability and allowing penetration in a non-dissociated form. 

Figure 1: Phytobiotic HygenPro® is protected by special matrix,
releasing its active components in controlled way along whole
digestive tract. 
Image credit: Liptosa
The bactericide and fungicide effects of certain combinations of essential oils is strengthened when acting in acid environment. In vitro studies confirm that essential oils inhibit formation of flagella in E. coli and stick together flagella of Salmonella spp. Essential oils apart from their bactericide effect, shows prebiotic properties, improving intestine integrity and modulating saprophyte microbiota.

That is why the use of combinations of organic acids together with essential oils confirms its efficacy especially in the control of intestinal dysbiosis, acting against both Gram-negative and Gram-positive bacterial pathogens.

The use of phytobiotics is specially justified in the diets for young animals, where immature stomachs and intestines do not reach the level of secretions high enough to digest in efficient way. Organic acids used in this phase allows to reduce the buffer capacity of the feed, its retention in stomach and intestine and increase feed intake together with reduction of the risk of diarrhoea.

The question mark about the use of phytobiotics is the correct choice of its active ingredients, dose and cost. Development of profitable solutions with a broad margin of safety can be achieved taking advantages of synergies exiting among different botanicals together with organic acids.

In the case of organic acids, the main doubt is about their efficacy in the distal parts of the intestine. Therefore, it is crucial to provide a product based on the technology of gradual and controlled release of active components, quickly for the stomach and small intestine and slowly for the components to be released in the distal parts of large intestine.

This goal may be achieved using special protection matrix, which acts independent of the presence of digestive juices, enzymes and pH levels (Figure 1.)

Read the full article, HERE.

The Global Miller
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which is published by Perendale Publishers Limited.

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