February 18, 2016

18/02/2016: Scientific study demonstrates slow release butyrate is effective replacement for antibiotic growth promoter

Image: Dano
Encapsulated ButiPEARL™ effective option for growth promoter in broilers

Recently, a novel and timely study evaluating the effect of a slow release calcium butyrate versus avilamycin was published in Poultry Science, an international journal publishing research notes, symposium papers and studies of basic science as applied to poultry. The timing of this study, which provides an effective alternative to antibiotic growth promoters, is critically important as the global trend and pressure to move away from antibiotics continues.

The alternative, butyric acid, is a short chain fatty acid which is known to be involved in mucosal immune response and to have an anti-inflammatory effect in animals. Although butyric acid is a small molecule, it can have diverse modes of action, such as increase villi height and crypt depth, leading to increases in absorptive surface of the small intestine and resulting in better nutrient utilisation.
Table 1. Animal performance data of ButiPEARL versus avilamycin
* significantly different from Control with P < 0.05
As butyrates are so quickly absorbed and metabolised, an encapsulation technology is needed in order to secure the slow release of the butyrate in the small intestine. 
ButiPEARL™ is a slow release calcium butyrate which has been tested in a C14 labelled study to have a targeted release of butyric acid in the small intestine [1].

In a recent study (Table 1), the efficacy of ButiPEARL versus avilamycin was studied. Both ButiPEARL (300 g/ton) and avilamycin (6 mg/kg active substance) treated groups were able to demonstrate a statistically significant difference versus the control group on body weight gain (BWG) and feed conversion ratio (FCR), which demonstrated their effect to improve performance.

Between the ButiPEARL and the avilamycin group, no statistically significant difference was observed. Birds in these two treatment groups had the thickest mucosa, and both ButiPEARL and avilamycin increased digestibility of several amino acids (e.g. threonine, serine and proline) at statistically significant levels.

This study demonstrates that ButiPEARL can improve digestion and absorption, and consequently bird performance results. Reference: Poultry Science 00:1-9 (2016), Table 1.

[1] Smith J et al. In Vitro Dissolution and In Vivo Absorption of Calcium [1-14C] Butyrate in Free or Protected forms. Journal of Agricultural Food Chemistry 2012.

Visit the Kemin site HERE.

The Global Miller
This blog is maintained by The Global Miller staff and is supported by the magazine GFMT
which is published by Perendale Publishers Limited.

For additional daily news from milling around the world: global-milling.com

No comments:

Post a Comment

See our data and privacy policy Click here