June 24, 2013

Toxinor, the wide spectrum mycotoxin binder

Over 300 types of mycotoxins are known, different in origin, structure and toxic characteristics. They are usually resistant to heat or chemical and biological degradation, besides being invisible, odourless and tasteless. 
Sometimes, synergistic effects might enhance their toxicity. Therefore, to tackle these different toxic compounds a multifaceted approach has to be employed. TOXINOR is a combination of ingredients with different physical properties and structure that confers the ability to sequester a range of mycotoxins based on many variables such as polarity, molecular size, etc... 
To be able to cover the maximum range of mycotoxins, NOREL decided to use three different ingredients that combines laminar 3D, fibrous-like and empty spheres structures, this way the specific surface value is maximised to optimise the activity against a range of mycotoxins, and to show a high binding capability for AFB1, AFB2, T-2, ZEN, Fumonisins and Ochratoxin. 
In order to assess its efficacy, TOXINOR was tested using HPLC in 10 toxins under two different pH conditions and compared with each control group. Results indicate a binding close to 100 percent for several toxins (Aflatoxins and Zearalenone), above 90 percent for Ochratoxin and T-2 toxin and a lower binding for Fumonisin and Vomitoxin.     

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chemical structure of the mycotoxin ochratoxin C
chemical structure of the mycotoxin ochratoxin C (Photo credit: Wikipedia)

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